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Vol. 36. Issue 2.
Pages 75-144 (March - April 2025)
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Vol. 36. Issue 2.
Pages 75-144 (March - April 2025)
Clinical Research

Relationship between NLR (Neutrophil/Lymphocyte ratio) value and clinical outcome in patients with external ventricular drainage due to intraventricular hemorrhage

Relación entre el valor NLR (relación neutrófilos/linfocitos) y el resultado clínico en pacientes con drenaje ventricular externo debido a hemorragia intraventricular
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Eylem Burcu Kahraman Özlü
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burcu.kahraman@gmail.com

Corresponding author.
, Kaan Durmuş, Elçin Tuğce Mutlu, Ezgi Akar, Selin Tural, Arif Tarkan Çalışaneller
Haydarpasa Numune Education and Research Hospital, Neurosurgery, Uskudar, Istanbul, Turkey
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Abstract
Background

Intraventricular hemorrhages (IVH) are common pathologies in neurosurgery practice and are associated with the worst clinical outcome among all intracranial hemorrhages. Blood in the ventricles is thought to worsen the clinical condition by triggering inflammatory processes. In recent years, NLR value is a frequently used inflammatory parameter, and there are many publications reporting that a high NLR value is an important marker in predicting the severity of inflammation.

Our study aimed to evaluate the effect of NLR values at admission on the clinical outcome of patients undergoing EVD due to IVH in our clinic.

Material and methods

In our study, age and gender data, admission Glasgow Coma Scale (GCS), NLR value at the time of admission and clinical status at discharge of 36 patients, who underwent EVD following IVH in our hospital neurosurgery clinic between 2019 and 2024, were examined.

Results

Of the 36 cases in our study, 16 were female and 20 were male. For all cases, the mean age was 61.88, and the mean GCS values at admission were calculated as 8.5. In the laboratory of our hospital, the normal NLR range was determined as 0.78-3.53, and the mean NLR values at admission were evaluated as 16.57. When the clinical outcomes of the cases were examined, it was seen that 30 cases ended with exitus after intensive care follow-up, and 6 cases were discharged with good clinical outcomes (GCS:15). The mean NLR value was calculated as 18.00 for the patients who ended with exitus and 8.12 for the patients discharged with good clinical outcomes.

Conclusion

NLR, which has been used to determine the severity of inflammation in recent years, has been reported to be a marker that can predict clinical outcomes of many diseases. In our study, NLR was observed to be high at admission in all cases, but it was significantly higher in the cases ending with exitus than in the cases not ending with exitus. As a result, it is thought that NLR value is a parameter that can be used to predict the clinical course in IVH patients undergoing EVD.

Keywords:
Neutrophil/Lymphocyte ratio
Intraventricular hemorrhage
Outcome
Abbreviations:
NLR
EVD
IVH
GCS
CRP
WBC
HT
DM
CAD
HF
AF
RA
CKD
DMD
MS
Resumen
Antecedentes

Las hemorragias intraventriculares (Hiv) son patologías comunes en la práctica de la neurocirugía y se asocian con el peor resultado clínico entre todas las hemorragias intracraneales. Se cree que la sangre en los ventrículos empeora la condición clínica al desencadenar procesos inflamatorios. En los últimos años, el valor NLR es un parámetro inflamatorio utilizado con frecuencia y hay muchas publicaciones que informan que un valor NLR alto es un marcador importante para predecir la gravedad de la inflamación.

Nuestro estudio tuvo como objetivo evaluar el efecto de los valores de NLR al ingreso sobre el resultado clínico de los pacientes sometidos a EVE debido a Hiv en nuestra clínica.

Material y métodos

En nuestro estudio se utilizaron datos de edad y sexo, escala de coma de Glasgow (GCS) al ingreso, valor de NLR en el momento del ingreso y estado clínico al alta de 36 pacientes, a los que se les realizó EVE tras Hiv en la clínica de neurocirugía de nuestro hospital entre 2019 y 2024, fueron examinados.

Resultados

De los 36 casos de nuestro estudio, 16 fueron mujeres y 20 hombres. Para todos los casos, la edad media fue de 61,88 años y los valores medios de GCS al ingreso se calcularon como 8,5. En el laboratorio de nuestro hospital, el rango normal de NLR se determinó entre 0,78-3,53 y los valores medios de NLR al ingreso se evaluaron como 16,57. Cuando se examinaron los resultados clínicos de los casos, se observó que 30 casos terminaron con exitus después del seguimiento en cuidados intensivos y 6 casos fueron dados de alta con buenos resultados clínicos (GCS:15). El valor medio del INL se calculó como 18,00 para los pacientes que terminaron con exitus y 8,12 para los pacientes dados de alta con buena evolución clínica.

Conclusión

Se ha informado que el NLR, que se ha utilizado para determinar la gravedad de la inflamación en los últimos años, es un marcador que puede predecir los resultados clínicos de muchas enfermedades. En nuestro estudio, se observó que el INL al ingreso era elevado en todos los casos, pero fue significativamente mayor en los casos que terminaron en exitus que en los casos que no terminaron en exitus. Como resultado, se cree que el valor NLR es un parámetro que puede usarse para predecir el curso clínico en pacientes con Hiv sometidos a EVE.

Palabras clave:
Relación neutrófilos/linfocitos
Hemorragia intraventricular
Resultado

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References
[1]
I. Barnaure, A.C. Liberato, R.G. Gonzalez, J.M. Romero.
Isolated intraventricular haemorrhage in adults.
Br J Radiol, 90 (2017),
[2]
P.D. LeRoux, M.M. Haglund, D.W. Newell, M.S. Grady, H.R. Winn.
Intraventricular hemorrhage in blunt head trauma: an analysis of 43 cases.
Neurosurgery, 31 (1992), pp. 678-684
[3]
P. Chiewvit, N. Danchaivijitr, Y. Nilanont, N. Poungvarin.
Computed tomographic findings in non-traumatic hemorrhagic stroke.
J Med Assoc Thai, 92 (2009), pp. 73-86
[4]
N. Badjatia, J. Rosand.
Intracerebral hemorrhage.
[5]
D.B. Herrick, N. Ullman, S. Nekoovaght-Tak, D.F. Hanley, I. Awad, S. LeDroux, et al.
Determinants of external ventricular drain placement and associated outcomes in patients with spontaneous intraventricular hemorrhage.
Neurocrit Care, 21 (2014), pp. 426-434
[6]
S.B. Batmaz.
Simple markers for systemic inflammation in pediatric atopic dermatitis patients.
Indian J Dermatol, 63 (2018), pp. 305-310
[7]
S. Balta, M. Cakar, S. Demirkol, Z. Arslan, M. Akhan.
Higher neutrophil to lymhocyte ratio in patients with metabolic syndrome.
Clin Appl Thromb Hemost, 19 (2013), pp. 579
[8]
D.H. Lee, B.K. Lee, S.M. Lee, Y.S. Cho, S.W. Yun.
Association of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with in-hospital mortality in the early phase of severe trauma.
Ulus Travma Acil Cerrahi Derg, 27 (2021), pp. 290-295
[9]
E. Mracsko, R. Veltkamp.
Neuroinflammation after intracerebral hemorrhage.
Front Cell Neurosci, 8 (2014), pp. 388
[10]
M. Dey, J. Jaffe, A. Stadnik, I.A. Awad.
External ventricular drainage for intraventricular hemorrhage.
Curr Neurol Neurosci Rep, 12 (2012), pp. 24-33
[11]
W.C. Ziai, S. Tuhrim, K. Lane, N. McBee, K. Lees, J. Dawson, CLEAR III Investigators, et al.
A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III).
Int J Stroke, 9 (2014), pp. 536-542
[12]
S. Tuhrim, D.R. Horowitz, M. Sacher, J.H. Godbold.
Volume of ventricular blood is an important determinant of outcome in supratentorial intracerebral hemorrhage.
Crit Care Med, 27 (1999), pp. 617-621
[13]
W.B. Young, K.P. Lee, M.S. Pessin, E.S. Kwan, W.M. Rand, L.R. Caplan.
Prognostic significance of ventricular blood in supratentorial hemorrhage: a volumetric study.
Neurology, 40 (1990), pp. 616-619
[14]
D.A. Graeb, et al.
Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis.
[15]
N.J. Naff.
Intraventricular hemorrhage in adults.
Curr Treat Options Neurol, 1 (1999), pp. 173-178
[16]
S. Lattanzi, F. Brigo, E. Trinka, C. Cagnetti, M. Di Napoli, M. Silvestrini.
Neutrophil-to-lymphocyte ratio in acute cerebral hemorrhage: a system review.
Transl Stroke Res, 10 (2019), pp. 137-145
[17]
F. Wang, S. Hu, Y. Ding, X. Ju, L. Wang, Q. Lu, et al.
Neutrophil-tolymphocyte ratio and 30-day mortality in patients with acute intracerebral hemorrhage.
J Stroke Cerebrovasc Dis, 25 (2016), pp. 182-187
[18]
F. Wang, L. Wang, T.T. Jiang, J.J. Xia, F. Xu, L.J. Shen, et al.
Neutrophilto-lymphocyte ratio is an independent predictor of 30-day mortalityof intracerebral hemorrhage patients: a validation cohort study.
Neurotox Res, 34 (2018), pp. 347-352
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