TY - JOUR T1 - Primary intracranial melanoma, amelanotic variant: Case report JO - Neurocirugía (English edition) T2 - AU - Andrés Sanz,Julio Alberto AU - Ruiz Ginés,Juan Antonio AU - Iliev,Hristo AU - Aguas Valiente,Jesús SN - 25298496 M3 - 10.1016/j.neucie.2022.02.005 DO - 10.1016/j.neucie.2022.02.005 UR - https://www.revistaneurocirugia.com/en-primary-intracranial-melanoma-amelanotic-variant-articulo-S2529849622000144 AB - Primary brain melanoma is a very rare tumour (only 0.07% of primary CNS neoplasms) which usually shows with abundant melanin content; whereas hypo/melanotic variants have been scarcely described.We introduce the case of a female patient with headache, left brachial paresis and frontallobar syndrome. The MRI image showed a right frontal mass with homogeneous contrast uptake. As treatment, a complete surgical resection was performed. Pathology was diagnostic for melanoma, with very low melanin content and a high proliferative index. A thorough extension study was performed to rule out an extracranial primary origin. Due to several intercurrent complications, the patient evolved unfavorably, not being able to receive further treatment.The amelanotic variant of primary intracranial malignant melanomas has not been described in detail previously. We will review the literature, focusing on the particularities of management and diagnosis of this clinical entity. ER -