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Vol. 27. Issue 2.
Pages 51-56 (March - April 2016)
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Vol. 27. Issue 2.
Pages 51-56 (March - April 2016)
Investigación clínica
Predictores de resangrado en pacientes con hemorragia subaracnoidea aneurismática y retardo del tratamiento neuroquirúrgico
Re-bleeding predictors in patients with aneurysmal subarachnoid haemorrhage and delayed neurosurgical treatment
Dannys Rivero Rodrígueza,
Corresponding author
damariv@infomed.sld.cu

Autor para correspondencia.
, Claudio Scherle Matamorosb, Leda Fernández Cúeb, José Luis Miranda Hernándezb, Yanelis Pernas Sánchezc, Jesús Pérez Nellarb
a Unidad de Ictus, Hospital «Comandante. Manuel Fajardo», , La Habana, Cuba
b Unidad de Ictus, Hospital «Hermanos Ameijeiras», La Habana, Cuba
c Medicina Interna, Hospital «Calixto García», La Habana, Cuba
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Tabla 1. Regresión logística
Resumen
Objetivo

Evaluar los factores predictores de resangrado en los pacientes con hemorragia subaracnoidea aneurismática y tratamiento neuroquirúrgico tardío.

Pacientes y método

Se realizó un estudio tipo cohorte prospectivo con los 261 pacientes atendidos en el Hospital Hermanos Ameijeiras en La Habana, Cuba, en el periodo comprendido entre octubre de 2005 y junio de 2014, con diagnóstico de hemorragia subaracnoidea aneurismática.

Resultados

En el análisis multivariado se encontró que los grados III y IV de las escalas de la Federación Mundial de Neurocirujanos (III-OR 2,01; 95% CI 1,06-3,84; IV-OR 3,84, 95% CI 2,06-7,31) y de Fisher (III-OR 2,04; 95% CI 1,01-4,13; IV-OR 2,12; 95% CI 1,05-4,28), los aneurismas localizados en la arteria comunicante anterior (OR 1,57; 95% CI 1,00-2,46) y de circulación posterior (OR 2,45; 95% CI 1,33-4,44), así como el antecedente personal de hipertensión arterial (OR 2,70; 95% CI 1,00-7,30) fueron asociados a un incremento del riesgo de resangrado, mientras que la cifras de tensión arterial, las de glucemia, los aneurismas múltiples y la localización en la arteria cerebral media no mostró esta relación.

Conclusiones

Los antecedentes de hipertensión arterial, los peores grados en las escalas de Fisher y de la Federación Mundial de Neurocirujanos, así como la localización de los aneurismas fueron factores de riesgo independientes de resangrado en pacientes con hemorragia subaracnoidea aneurismática y tratamiento neuroquirúrgico tardío.

Palabras clave:
Enfermedad cerebrovascular
Hemorragia subaracnoidea
Aneurisma intracraneal
Resangrado
Abstract
Objective

To evaluate the re-bleeding predictors in patients with delayed treatment of aneurysmal subarachnoid hemorrhage.

Patients and methods

A prospective cohort study enrolled 261 patients with aneurysmal subarachnoid hemorrhage, attending in Hermanos Ameijeiras Hospital from October 2005, and June 2014.

Results

An increased re-bleeding risk in the multivariate analysis was associated with grade III (OR 2.01; 95% CI; 1.06-3.84) and grade IV (OR 3.84; 95% CI; 2.06-7.31) on World Federation Neurological Surgeon (WFNS) scale; grade III (OR 2.04; 95% CI; 1.01-4.13) and grade IV (OR 2.12, 95% CI; 1.05-4.28) on the Fischer scale, aneurism location in posterior circulation (OR 2.45, 95% CI; 1.33-4.44), and anterior communicant artery (OR 1.57, 95% CI;1.00-2.46). Hypertension history was present in 60.9% (159 patients) and was also associated with risk of re-bleeding (OR 2.70, 95% CI; 1.00-7.30). Blood pressure, haematocrit, glycemic, aneurysm size, multiple aneurysms, and location in the middle cerebral artery, do not show any relationship.

Conclusion

Hypertension history, poor grade (III and IV) on WFNS and Fisher scale and aneurysm location were independent risks factors of re-bleeding in patients with delayed aneurysmal treatment.

Keywords:
Cerebrovascular disease
Subarachnoid haemorrhage
Intracranial aneurysm
Rebleeding

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