Neurocirugía Neurocirugía
Neurocirugia. 1994;05:10-5. - Vol. 05 Núm.01 DOI: 10.1016/S1130-1473(94)71116-7

Influencia de la actinomicina D sobre el flujo sanguíneo cerebral en un modelo de isquemia experimental

G. Posadas Narroa, J. de Raro del Morala, J. Vaquero Crespoa, C. San Juan Roblesa, G. Bravo Zabalgoitiaa, J. Ortiz Berrocala

a Servicios de Neurocirugía y Medina Nuclear. Clínica Puerta de Hierro. Universidad Autónoma de Madrid-España

Palabras clave

Isquemia. Actinomicina D. Flujo sanguíneo cerebral.

Resumen

Existen estudios experimentales sobre el mejoramiento del vasoespasmo que sigue a la hemorragia subaracnoidea por la Actinomicina D, pero no existe ningún estudio acerca de su efecto en la isquemia cerebral.

Hemos realizado el presente estudio experimental en 18 ratas; produciéndoles isquemia cerebral parcial (mediante ligadura permanente de la arteria carótida común derecha, y clipaje transitorio de la carótida común izquierda), que fueron tratadas con Actinomicina D (vía intraperitoneal) por 5 días. Se administró dicha sustancia a las 6 y 12 horas postisquemia, en los grupos A (6 ratas) y B (6 ratas) respectivamente. El grupo C (control) constituído también por 6 ratas, no recibió tratamiento alguno. El análisis estadístico antes y después del tratamiento se realizó observando las modificaciones del flujo sanguíneo cerebral utilizando HMPAO marcado con Tc-99m (marcador radioactivo).

Se encontró ausencia de modificación del flujo sanguíneo cerebral, y por lo tanto ausencia de mejoría de la isquemia cerebral.

Se concluye que la Actinomicina D no modifica el flujo sanguíneo ni mejora la isquemia cerebral experimental en ratas.

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