Journal Information
Vol. 15. Issue 4.
Pages 366-371 (January 2004)
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Vol. 15. Issue 4.
Pages 366-371 (January 2004)
Niveles atérmicos de corrientes eléctricas usadas en terapia por transferencia eléctrica capacitiva inducen efectos citotóxicos parciales en cultivos de neuroblastoma humano
Nonthermal levéis of electric currents applied in capaci-tive electric transfer therapy provokes partial cytotoxic effects in human neuroblastoma cultures
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1973
M.L. Hernández-Bule, M.A. Trillo, M.A. Martínez-Pascual, J. Leal, A. Úbeda
Servicios de Investigación-BioElectroMagnetismo. Hospital Ramón y Cajal. Madrid
E. Bazán*
* Servicios de Investigación-Neurobiología. Hospital Ramón y Cajal. 28034 Madrid.
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Resumen

El presente estudio investiga la respuesta celular a corrientes eléctricas débiles, de señal sinusoidal y 0,5 MHz. La aplicación experimental de corrientes con idéntica señal, pero de intensidad suficientemente elevada como para incrementar significativamente la temperatura de los tejidos blanco, ha proporcionado respuestas satisfactorias en el tratamiento clínico de tumores cerebrales mediante terapia térmica por transferencia eléctrica capacitiva (TEC). Los resultados del presente trabajo muestran que la exposición in vitro a niveles atérmicos de señal TEC provoca efectos citotoxicos en células de neuroblastoma humano. Tal respuesta parece estar mediada por alteraciones en el ciclo celular. En su conjunto, los resultados sugieren que la potencial eficacia terapéutica de la técnica TEC podría obedecer a una acción sinérgica entre una respuesta tisular a los efectos térmicos del paso de la corriente más, una respuesta celular atérmica a la propia señal eléctrica.

Palabras clave:
Electroterapia
Transferencia eléctrica capacitiva
Neuroblastoma
Hipertermia
Ciclo celular
Abreviaturas:
AMPc
CET
DMEM
FBS
NB69
TEC
μA/mm2
MHz
mM
W
Summary

The present study investigates the cellular res-ponse to weak, sine wave, 0.5-MHz electric currents. The experimental exposure to identical signals at an intensity high enough as to significantly increase the temperature in target tissues, has provided positive res-ponses in clinical treatments of tumors with capacitive electric transfer (CET) thermal therapy. The present results show that the in vitro exposure to CET signals at athermal doses causes cytotoxic effects in human neuroblastoma cells. Such a response seems to be due to signal-induced alterations in the cell cycle. As a whole, the results suggest that the potential therapeutic effects of the CET strategy could be due to the thermal response of the tissues to the currents, added to an athermal response of the cells to the electric current itself.

Key words:
Electrotherapy
Capacitive electric transfer
Neuroblastoma
Hyperthermia
Cell cycle

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