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Vol. 15. Issue 6.
Pages 590-595 (January 2004)
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Vol. 15. Issue 6.
Pages 590-595 (January 2004)
Metástasis en el sistema nervioso central: biología molecular
Metástasis tumors of the central nervous system: molecular biology
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M. Josefa Bello
, P. González-Gómez, J.A. Rey
Laboratorio de Oncogenetica Molecular y Epigenetica del Cáncer, Unidad de Investigación, Departamento de Cirugía Experimental, Hospital Universitario “La Paz”. Madrid
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Resumen

Las metástasis en el sistema nervioso representan un importante y creciente problema en la práctica clínica, siendo causa de gran mortalidad en los países desarrollados. En este artículo revisamos los escasos datos existentes hasta el momento acerca de los mecanismos moleculares implicados en la patogénesis de las metástasis en el sistema nervioso, que incluyen diversas alteraciones genéticas, en genes supresores de tumores y oncogenes, así como la alteración del equilibrio epigenético de la célula. Concluimos que en un futuro un mayor conocimiento de dichos mecanismos moleculares contribuirán a un mejor diagnóstico, tratamiento y evolución clínica de estos pacientes.

Palabras clave:
Metástasis en el sistema nervioso
Biología molecular
GST
Oncogen
Metilación
Abreviaturas:
DAP-Kinasa
DCC
EGFR
GSTP-1
HCG
MDR-1
MGMT
MMP-2
PTEN
RB 1
THBS1
TIMP-3
VEGF
Summary

Metastases in the nervous system represent an important and growing problem in the clinical practice, being the cause of a great mortality in the developed countries. This article reviews the few data available on the molecular mechanisms involved in the pathogenesis of these tumours, leading to oncogene activation, inactivation of tumour suppresor genes, not only by the clasical mechanisms, but also by the tumour cell epigenetic balance alteration. We conclude that all this knowledge will lead in the future to a better diagnosis, treatment and clinic evolution of these patients.

Key words:
Metastatic tumours of the nervous system
Molecular biology
TSG
Oncogene
Methylation

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