Publish in this journal
Journal Information
Vol. 22. Num. 6.January 2011Pages 488-607
Download PDF
More article options
Vol. 22. Num. 6.January 2011Pages 488-607
DOI: 10.1016/S1130-1473(11)70115-4
Lung carcinoma metastasis presenting as a pineal region tumor
Metástasis del carcinoma de pulmón que se presenta como tumor de la región pineal
Y. Samanci??
Corresponding author

Corresponding. Neurosurgery Clinic, Ministry of Health Okmeydani Education and Research Hospital. Istanbul, Turkey.
, C. Iplikcioglu, E. Ozek
Neurosurgery. Ministry of Health Okmeydani Education and Research Hospital. Istanbul Turkey
D. Ozcan*
* Pathology Departments. Ministry of Health Okmeydani Education and Research Hospital. Istanbul Turkey
B. Marangozoglu**
** Department of Neurology. Istanbul University. Istanbul Faculty of Medicine. Istanbul. Turkey
This item has received
Article information

The pineal region is an unusual site for brain metastasis and most metastatic pineal lesions are asymptomatic. A 53 year-old man presented with severe headache, limitation of upward gaze and diplopia. The patient's neurological examination was unremarkable. Magnetic resonance imaging (MRI) scans of the brain demonstrated a 1,5×2cm well demarcated solitary mass in the pineal region with hydrocephalus. Surgery was performed and adenocarcinoma was diagnosed. A systemic investigation revealed adenocarcinoma of the lung as primary lesion. Although rare, metastatic tumor should be considered in the differential diagnosis of pineal region tumors.

Key words:
Pineal region
Lung carcinoma
Pineal tumor

La región pineal es un sitio inusual para el depósito de metástasis y la mayoría de las metástasis pineales son asintomáticas. Un hombre de 53 años debutó con una cefalea intensa, limitación en la supraversión y diplopia. La exploración neurológica fue irrelevante. La resonancia magnética (RM) cerebral demostró una lesión solitaria de 1,5×2cm bien delimitada, en la región pineal con hidrocefalia. Fue intervenido quirúrgicamente siendo el diagnóstico anatomopatológico de adenocarcinoma. Un estudio sistémico descubrió un adenocarcinoma de pulmón como tumor primario. Aunque muy raramente, las metástasis deben considerarse en el diagnóstico diferencial de tumores de la región pineal.

El Texto completo solo está disponible en PDF
P. Brasseur,F. Sukkarieh,H. Dupont,D. Brohee
Pineal body metastasis
J Belge Radiol, 77 (1994), pp. 162-163
J.M. Bruner,R.D. Tien
Secondary tumors
6th edn, pp. 419-450
J.L. Chason,F.B. Walker,J.W. Landers
Metastatic carcinoma in the central nervous system and dorsal root ganglia
Cancer, 16 (1963), pp. 781-787
S. Czirjak,D. Vitanovic,F. Slowik,A. Magyar
Primary meningeal melanocytoma of the pineal region. Case report
J Neurosurg, 92 (2000), pp. 461-465
M.S.B. Edwards,R.J. Hudgins,C.B. Wilson
Pineal region tumors in children
J Neurosurg, 68 (1988), pp. 689-697
R. Enriquez,B. Egbert,J. Bullock
Primary malignant melonoma of central nervous system. Pineal involvement in a patient with nevus of ota and multiple pigmented skin nevi
Arch Pathol, 95 (1973), pp. 392-395
Ein fall von markschwamm mit ungewohnlich vielfacher metastatischer verbreitung
Arch Path Anat, 13 (1858), pp. 271-274
L.H. France
Contribution to the study of 150 cases of cerebral metastases
J Neurosurg Sci, 4 (1975), pp. 189-210
R.J. Freilich,S.J. Thompson,R.W. Walker,M.K. Rosenblum
Adenocarcinomatous transformation of intracranial germ cell tumors
Am J Surg Pathol, 19 (1995), pp. 537-544
B. Halpert,E.E. Erickson,W.S. Fields
Intracranial involvement from carcinoma of the lung
AMA Arch Pathol, 69 (1960), pp. 93-103
J. Hirato,Y. Nakazato
Pathology of pineal region tumors
J Neurooncol, 54 (2001), pp. 239-249
R.O. Holness,V.E. Sangalang
Myelomatous metastases to the pineal body
Surg Neurol, 5 (1976), pp. 97-100
J.E. Joyner
Metastatic gastric adenocarcinoma to the pineal body. A case report
Acta Neuropathol, 1 (1962), pp. 416-419
A. Kakita,K. Kobayashi,N. Aoki,I. Eguchi,T. Morita,H. Takahashi
Lung carcinoma metastasis presenting as a pineal region tumor
Neuropathology, 23 (2003), pp. 57-60
H. Kanai,K. Yamada,N. Aihara,K. Watanabe
Pineal region metastasis appearing as hypointensity on T2-weighted magnetic resonance imaging
Neurol Med Chir (Tokyo), 40 (2000), pp. 283-286
S. Kashiwagi,M. Hatano,T. Yokoyama
Metastatic small cell carcinoma to the pineal body: Case report
Neurosurgery, 25 (1989), pp. 810-813
A. Keyaki,Y. Makita,S. Nabeshima
Pineal metastatic tumor from lung cancer initially caused by neurological abnormalities of pineal body tumor
No Shinkei Geka, 17 (1989), pp. 495-499
F.W. Kreth,C.H. Schatz,A. Pagenstecher,M. Faist,B. Volk,C.B. Ostertag
Stereotactic management of lesions of the pineal region
Neurosurgery, 39 (1996), pp. 280-291
S. Lauro,L. Trasatti,C. Capalbo,P.L. Mingazzini,A. Vecchione,C. Bosman
Unique pineal gland metastasis of clear cell renal carcinoma: case report and review of the literature
Anticancer Res, 22 (2003), pp. 3077-3080
M. Matsutani,K. Sano,K. Takakura
Primary intracranial germ cell tumors: A clinical analysis of 153 histologically verified cases
J Neurosurg, 86 (1997), pp. 446-455
S. Oi,K. Matsuzawa,J.U. Choi
Identical characteristics of the patient populations with pineal region tumors in Japan and in Korea and therapeutic modalities
Childs Nerv Syst, 14 (1998), pp. 36-40
P. Ortega,N. Malamud,M. Shimkin
Metastasis to the pineal body
Arch Pathol, 52 (1951), pp. 518-528
R. Ouyang,B. Rozdilsky
Metastases of carcinoma to the pineal body
Arch Neurol, 15 (1966), pp. 399-403
J. Pecker,J.M. Scarabin,B. Vallee,J.M. Brucher
Treatment in tumours of the pineal region. Value of stereotaxic biopsy
Surg Neurol, 12 (1979), pp. 341-348
R. Ramina,M. Coelho Neto,W.M. Mariushi,W.O. Arruda
Pineal metastasis as first clinical manifestation of colorectal adenocarcinoma. Case report
Arq Neuropsiquiatr, 57 (1999), pp. 92-95
J. Regis,P. Bouillot,F. Rouby-Volot,D. Figarella-Branger,H. Dufour,J.C. Peragut
Pineal region tumors and the role of stereotactic biopsy. Review of the mortality, morbidity, and diagnostic rates in 370 cases
Neurosurgery, 39 (1996), pp. 907-914
D.S. Russell,L.J. Rubinstein
Pathology of Tumors of the Nervous System
Williams & Wilkins, (1977)
J.M. Schuster,R.C. Rostomily,C. Hahn,H.R. Winn
Two cases of esophageal carcinoma metastatic to the pineal region with a review of the literature
Surg Neurol, 49 (1998), pp. 100-103
D. Screiber,K. Bernstein,J. Schneider
Tumor metastasen im Zentralnervensystem. Eine prospektive Studie. 3. Mitteilung: Metastasen in Hypophyse. Epiphyse und Plexus chorioidei
Zentralbl Allg Pathol, 126 (1982), pp. 64-73
J.Q. Trojanowski,N.A. Tascos,L.B. Rorke
Malignant pineocytoma with prominent papillary features
Cancer, 50 (1982), pp. 1789-1793
T. Umahara,M. Kikawada,H. Arai,T. Iwamoto,M. Takasaki,Y. Hirabayashi,M. Kudo,K. Tsuchiya,H. Shimada
An autopsy case of multiple myeloma with pineal body and spinal cord dura mater infiltration
No To Shinkei, 49 (1997), pp. 655-658
J. Vaquero,S. Coca,R. Martinez,J. Escandon
Papillary pineocytoma. Case report
J Neurosurg, 73 (1990), pp. 135-137
J. Vaquero,R. Martinez,R. Magallon,J. Ramiro
Intracranial metastases to the pineal region. Report of three cases
J Neurosurg Sci, 35 (1991), pp. 55-57
R. Voorhies,N. Sunaresan,H. Thaler
The single supratentorial lesion. An evaluation of preoperative diagnostic tests
J Neurosurg, 53 (1980), pp. 364-368
P. Weber,K.V. Shepard,S. Vijayakumar
Metastases to pineal gland
Cancer, 63 (1989), pp. 164-165
H. Yanamoto,K. Kakita,S. Fukuma
Pineal metastasis. A case report and a review of literature
No Shinkei Geka, 15 (1987), pp. 1329-1334

Samanci, Y.; Iplikcioglu, C.; Ozek, E.; Ozcan, D.; Marangozoglu, B.: Lung carcinoma metastasis presenting as a pineal region tumor. Neurocirugía 2011; 22: 579–582.

Copyright © 2011. Sociedad Española de Neurocirugía
Neurocirugía (English edition)

Subscribe to our Newsletter

Article options
Cookies policy
To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.