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Vol. 26. Num. 5.September - October 2015
Pages 209-260
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Vol. 26. Num. 5.September - October 2015
Pages 209-260
Case Report
DOI: 10.1016/j.neucir.2014.12.004
Isolated neurosarcoidosis mimicking intracranial tumours – Analysis of 3 cases
Neurosarcoidosis aislada imitando tumores intracraneales – análisis de tres casos clínicos
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Karol Wiśniewskia,
Corresponding author
karol.lek@poczta.fm

Corresponding author.
, Rafał Wójcika, Wielisław Papierzb, Agata Majosc, Dariusz J. Jaskólskia
a Department of Neurosurgery and Neurooncology, Medical University of Lodz, Barlicki University Hospital, Kopcińskiego 22, Lodz 90-153, Poland
b Department of Pathomorphology, Medical University of Lodz, Czechoslowacka 8/10, Poland
c Department of Radiology, Medical University of Lodz, WAM University Hospital Lodz, Żeromskiego 113, Poland
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Abstract

Isolated neurosarcoidosis (INS), as a disease of low prevalence, is commonly overlooked in differential diagnosis, and its discovery on histopathological examination usually comes as a surprise. Preoperative diagnosis is difficult because the clinical picture of INS is non-specific. Its symptoms depend on the location of the lesions, and the MRI results are similar to those found in meningiomas or optic nerve gliomas. Although up to 5% of all sarcoidosis patients present with neurological symptoms, those with INS are exceptionally infrequently encountered.

Three cases of INS are presented here, analysing their clinical course and radiological images, in order to determine characteristic traits that might lead to a correct diagnosis.

Keywords:
Isolated neurosarcoidosis
Neurosarcoidosis clinical manifestations
Neurosarcoidosis MRI
Brain tumour diagnosis
Meningioma
Optic nerve glioma
Resumen

La neurosarcoidosis aislada (Isolated neurosarcoidosis - INS), como enfermedad de prevalencia baja, a menudo no es tomada en consideración en el diagnóstico diferencial, entonces su descubrimiento en los estudios histológicos generalmente llega inesperadamente. El diagnóstico preoperatorio es difícil porque el cuadro clínico de la INS no es específico pues sus síntomas dependen sólo de la localización de las lesiones, mientras que los resultados de RM son parecidos a los encontrados en los meningiomas o gliomas del nervio óptico. Aunque hasta el 5% de todos los pacientes con sarcoidosis presentan síntomas neurológicos, aquellos con INS se encuentran excepcionalmente.

Presentamos tres casos de INS, analizando su curso clínico y la imagen radiológica para determinar unos síntomas típicos que podrían ayudar a realizar el diagnóstico correcto.

Palabras clave:
Neurosarcoidosis aislada
Neurosarcoidosis manifestaciones clínicas
Neurosarcoidosis RM
Diagnóstico de tumour cerebral
Meningioma
Glioma del nervio óptico

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