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Vol. 20. Issue 4.
Pages 360-366 (January 2009)
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Vol. 20. Issue 4.
Pages 360-366 (January 2009)
Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model
Comparación entre la eficacia del Oxiplex y del Gore-Tex en un modelo experimental de fibrosis peridural
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G. Kurt, B. Cemil
, E. Durdag, N. Ceviker
Departments of Neurosurgery. Gazi University School of Medicine. Ankara. Turkey
O. Erdem*, B. Celik**
*. Departments of Pathology. Gazi University School of Medicine. Ankara. Turkey
** Department of Neurosurgery. Guven Hospital. Ankara. Turkey
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Summary
Objective

The authors conducted a study to compare the effectiveness of Oxiplex and Gore-tex in preventing postlaminectomy peridural fibrosis in rats. Peridural fibrosis is a common cause of pain in patients undergoing spinal surgery. To prevent scar formation numerous materials and methods have been employed such as non steroidal anti-inflammatory drugs (NSAIDs), Gelfoam, Oxiplex, Gore-tex, carboxymethil cellulose, Adcon-L, autogenous adipose grefting, mitomisin, and radiotherapy have been investigating for a long time, but only moderate success has been obtained.

Methods

Laminectomies were performed at the fourth lumbar vertebra (L-4) in 30 rats. Oxiplex or Gore-Tex was applied over the dura mater with the aim to perform a blinded evaluation of their effects. In the control group, only a L-4 laminectomy was performed. Animals were sacrificed 28 days after the surgical procedure. The extent of peridural fibrosis was evaluated on spine specimens by histological analysis.

Results

Both groups of animals treated with either Oxiplex or Gore-Tex showed a significant reduction in the degree of peridural fibrosis as compared to the control group. However no significant difference in the prevention of peridural fibrosis was observed between the Oxiplex and Gore-Tex groups.

Conclusions

This experimental model has shown that Oxiplex and Gore-Tex are effective methods to prevent peridural fibrosis and dural adhesions at the postlaminectomy areas.

Key words:
Peridural fibrosis
Oxiplex
Gore-Tex
Failed back syndrome
Resumen
Objetivo

Los autores realizaron un estudio para comparar la eficacia de Oxiplex y Gore-tex en la prevención de fibrosis peridural tras laminectomías en ratas. La fibrosis peridural es una causa común de dolor en pacientes sometidos a cirugía de la columna vertebral. Para evitar la formación de cicatriz, se han empleado numerosos materiales y métodos como los antiinflamatorios no esteroideos (AINE), Gelfoam, Oxiplex, Gore-tex, carboxymethil celulosa, Adcon-L, injertos de grasa antóloga, mitomicina o la radioterapia, pero sólo se ha obtenido resultados exitosos en pocas ocasiones.

Métodos

Se realizaron laminectomías en la cuarta vértebra lumbar (L-4) en 30 ratas. Se aplicaron Oxiplex o Gore-Tex sobre la duramadre con el objetivo de realizar una evaluación ciega de sus efectos. En el grupo control, sólo se realizó la laminectomía L4. Los animales fueron sacrificados 28 días después de la intervención quirúrgica. El grado de fibrosis peridural se evaluó sobre la columna vertebral de especímenes por análisis histológico.

Resultados

Ambos grupos de animales tratados con Oxiplex o Gore-Tex mostraron una reducción significativa en el grado de fibrosis peridural en comparación con el grupo control. Sin embargo, ninguna diferencia significativa en la prevención de la fibrosis peridural se observó entre los grupos de Oxiplex y Gore-Tex.

Conclusiones

Este modelo experimental ha demostrado que Oxiplex y Gore-Tex son métodos eficaces para prevenir la fibrosis peridural y adherencias en la duramadre tras laminectomías.

Palabras clave:
Fibrosis peridural
Oxiplex
Gore-Tex
Síndrome de la Cirugía Raquídea Fracasada

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